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Posted by john on July 9th, 2007 — in Flonase Top News
Most of us long for the spring and summer months but for many it can spell itchy eyes, a running nose and constant sneezing. Health Reporter JANE PICKEN finds out more about hay fever hell.
Phamacist Neil Jordan sees up to 100 hay fever sufferers a week during the peak summer months
ALLERGY-prone Trudy Hathaway has sneezed so much this summer with hay fever that she pulled a muscle in her neck.
And to make matters worse, she is waging a daily war with itchy, swollen eyes, a streaming nose and a puffy face – all thanks to tiny pollen particles which are invisible to the naked eye but litter the air at this time of year.
“Everyone is moaning with all the rain at the moment, but I love it because it clears the pollen and eases my symptoms,” says Trudy, still managing to have a giggle about the situation.
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“It does get very bad, though, and there has been times when my face and eyes have been really swollen. Sometimes it’s hell because I look haggard with red and swollen eyes.
“I can feel the symptoms coming on straight away as soon as I get up, and if I take the treatment in time it can be OK, but I can always tell before they’ve even started.
“But I’m so used to it now that I don’t let it stop me going out. Although it does affect some things – there is no point wearing make-up if I start sneezing, because my eyes water and it all comes off.”
It is not just hay fever that plagues the 29-year-old’s life, as Trudy is also allergic to a wealth of products and materials, including latex, aerosols, leather, rubber, garlic and onions, to name just a few.
Her chronic allergies and hay fever, which was diagnosed 10 years ago, made working as a hairdresser impossible and last October she was forced to give up a promising career in the profession.
Trudy, who lives with parents Richard, 63, and June, 58, in Throckley, Newcastle, explained: “I’d just finished my training, but I really couldn’t go on as the products and the work were making my hand so red, scabby and sore.
“Silly things, like putting my hands on door handles for too long can also make my skin flare up. Now I’m taking antihistamines and nasal spray for my hay fever, and if I didn’t take those I’d spend the whole time sneezing.
“But since I pulled a muscle in my neck last week, I’ve got to take strong painkillers and Diazepam to help me sleep.”
Hay fever, also known as seasonal allergic rhinitis, is a common condition which affects 20% of people in the UK. It is caused by airborne irritants, such as grass or tree pollens.
Spring and summer are key times for people suffering with the condition, as from May to July grass and flowers are in pollen, and from March to May pollen from trees are the most common cause of hay fever.
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The symptoms could be mistaken for a common cold, but medics are urging people to be aware of the differences. Symptoms of hay fever, caused by the body having a bad reaction to pollen, include:
# A runny or blocked and itchy nose
# Watery and itchy eyes
# Repeated sneezing
# Itchy throat and ears
# Possible face pain and headaches.
When the body comes into contact with pollen, cells in the lining of your nose, mouth and eyes release a chemical called histamine that triggers an allergic reaction.
“Hay fever can be really quite disabling,” points out GP Mike Scott, based at a clinic in Newburn, Newcastle.
“You have cells which are mostly in the nose and eyelids which become sensitised to certain types of pollen, and when exposed to it the cells release histamines which cause the irritation.
“The difference between hay fever and a common cold is that with the latter you’re likely to have a temperature and it would last less time. A cold is usually over in about a week, whereas hay fever can last a few months.”
Dr Scott adds: “Hay fever tends to go with eczema and asthma, and it’s a condition which usually runs in families. It’s also something which is most likely to present in childhood.”
The condition is usually treated with a nasal spray, antihistamine tablets or eye drops, but in more extreme case doctors can prescribe a short course of steroid tablets.
Pharmacist Neil Jordan sees up to 100 hay fever sufferers a week during the spring and summer at his New York Pharmacy, in New York village, North Tyneside.
Mr Jordan, who has been a pharmacist for more than 20 years, said: “The symptoms started very early this year and we even had people coming to see us in April during a bout of good weather.
“It’s amazing how many people don’t realise they’re suffering from hay fever. But once they’ve been diagnosed they usually go for antihistamine tablets.
“Eye drops can stop the cells producing histamines and act very quickly, just like the tablets. The nasal spray works to reduce the inflammation and irritation, but can take up to two weeks to kick in.”
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Posted by john on July 6th, 2007 — in Flonase Top News
In the war against food allergy, a vital molecule has been identified as a potential target for therapy.
There is currently no way to treat food allergy and the only way for sufferers to manage the problem is to avoid certain foods and make sure they have injectable adrenaline at hand.
Scientists led by Dr Claudio Nicoletti at the Institute of Food Research in Norwich have found that a molecule called Interleukin-12 (IL-12) is absent during allergic responses. Dr Nicoletti suggests that by delivering an allergen in the presence of IL-12, allergic reactions could be brought back under control.
“A food protein can be perfectly harmless to one person and lethal to another,” said Dr Nicoletti. “We have identified the missing molecule that normally keeps immune responses under control and appropriate.”
Having a food allergy means that the immune system responds to a food protein as if it was harmful. The immune system produces immunoglobulin E (IgE) antibodies, which normally help the body fight parasites. In the most severe cases individuals can suffer life-threatening reactions, including anaphylactic shock.
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In previous research, Dr Nicoletti found that special types of white blood cells called dendritic cells are important in helping the immune system decide on how to respond to foreign molecules. In the latest research, Dr Nicoletti compared the activity of dendritic cells in the gut and in the spleen of allergic and allergy resistant mice. He found that in the gut of susceptible mice, dendritic cells have stopped producing IL-12.
This research was carried out in collaboration with the University of Siena.
“We have identified a molecule that is very important for the regulation of immune response and for the first time clearly represents a potential target for the therapy of allergy. This is currently under investigation,” said Dr Nicoletti.
David Reading, director of the Anaphylaxis Campaign, said: “Food allergy can place an extremely heavy burden on the families affected. We welcome this research and look forward to further developments.”
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Posted by john on July 2nd, 2007 — in Flonase Top News
British scientists say a molecule called interleukin-12 can protect against food allergies.
A team at the Institute of Food Allergy Research in Norwich noted that interleukin-12 is absent during the body’s allergic response.
“We have identified a molecule that is very important for the regulation of immune response and for the first time clearly represents a potential target for the therapy of allergy. This is currently under investigation,” lead researcher Claudio Nicoletti said in a prepared statement.
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The molecule is made by white blood cells called dendrites. These cells help regulate the body’s immune response to foreign materials, including food proteins. There is no cure for food allergies other than avoiding the offending foods. For some people, food allergies can be life-threatening.
Researchers compared dendritic cells in the gut and spleen of mice with and without food allergies. Cells in the allergic mice did not make interleukin-12, the research team reported.
The discovery helps explain how “a food protein can be perfectly harmless to one person and lethal to another,” Nicoletti said. “We have identified the missing molecule that normally keeps immune responses under control.”
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Posted by john on June 30th, 2007 — in Flonase Top News
A graduate student at the Hebrew University of Jerusalem may have come up with a novel method for ridding the body of allergies and asthma, according to a report released by ScienceDaily.
The mast cell, with granules shown.
Credit: Yahoo images
Copyright: Yahoo images
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Ido Bachelet, a Ph.D. student, was awarded this year’s Barenholz Prize for Creativity and Originality in Applied Research for his ingenious approach to the eradication of the allergic response, which until now has no real cure.
While allergy is viewed as more of an annoyance than a serious disease, globally, over 250,000 individuals died from allergic response in 2005 alone. Death is due largely to complications from conditions such as asthma, and lethal shock reactions to food and snake and insect venoms.
The main culprits of the allergic response are mast cells. These cells, also called mastocytes, reside in loose connective tissue and contain many fine granules composed of histamine and heparin.Upon exposure to pathogens, mast cells release the contents of their granules, causing symptoms such as stuffy nose, rash, and even airway constriction. These symptoms are a necessary part of immune defense and wound healing, but they can easily escalate out of control with exposure to common allergens such as pollen. Furthermore, the mast cells attract other inflammatory cells, which serve to maintain the immune response at chronic levels.
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Bachelet first identified a key receptor found on the surface of mast cells, termed CD300a. When engaged, this receptor “turns off” mast cell activity. Unfortunately, the receptor is also found on other immune cells, so targeting just the receptor alone can result in general immune suppression.
To work around this issue, Bachelet and his colleague, Ariel Minitz, designed a synthetic antibody that is able to bind not only the CD300a receptor, but also a marker specific to mast cells themselves. This allows the antibody to bind specifically to mast cells, not just general immune cells.
When tested on mice exposed to various allergens, the antibody was able to eradicate at least four allergic diseases in the mice. The antibody, when administered in nose drops, also eliminated severe chronic asthma in the mice in the space of about two months.
Bachelet and his colleagues are hopeful that this antibody will be used for allergy treatment in the future.
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Posted by john on June 25th, 2007 — in Flonase Top News
Natural prebiotic ingredients supplier Orafti has announced the launch of a long-term study to look at the effects of prebiotic infant formulae supplemented with BeneoSynergy1 (oligofructose-enriched inulin) on the development of the neonatal immune system and the incidence of allergy in infants. The study is part of the EARNEST project, a EU-funded Integrated Project in the 6th Framework Programme, aiming to assess the importance of early nutrition on the modulation of adult disease risk. EARNEST is an Integrated Project in the EU 6th Framework Programme. The acronym EARNEST stands for EARly Nutrition programming-long term follow up of Efficacy and Safety Trials and integrated epidemiological, genetic, animal and consumer economic research.
There is a growing body of evidence to support the notion that early nutrition can play an important role in the prevention of disease later in life. Early findings by Barker and colleagues (1989) demonstrated a link between the risk of heart disease and maternal nutrition (foetal birth weight). With the increasing prevalence of allergic diseases, especially among infants over the past 35-40 years, new evidence has also pinpointed the effects of early nutrition on the occurrence of allergies. It has been suggested that reduced microbial stimulation during infancy and early childhood may be the cause - slowing down the maturation of the immune system and the development of an optimal balance between Th1- and Th2- like immunity.
Prebiotic ingredients, like inulin and oligofructose, selectively stimulate the growth and activity of endogeneous bifidobacteria and lactobacilli, thus improving gut health and modulating immune response. Therefore, inulin and oligofructose are expected to play an important role in lowering immune responses towards an allergy-like phenotype - a role which the EARNEST Project aims to explore further.
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Douwina Bosscher, Nutrition Research Manager at ORAFTI, comments, “We have a long standing history of participating in EU-projects and we are fully committed to investing our time and efforts into the EARNEST Project. This large collaborative scientific investigation brings together a hugely respected and influential multi-disciplinary team of scientists from academia and industry across Europe. The study will investigate early nutrition programming using an approach which integrates knowledge from randomised controlled trials, prospective observational studies, as well as animal, cellular and molecular techniques. It is hoped that the conclusion of the study in 2010 will enable a better understanding of the extent to which nutritional influences in early life can modulate a person’s development, metabolism and health in adulthood.”
A major focus of EARNEST is to perform controlled intervention studies into the early nutritional programming of diseases and how dietary factors can modulate their development. The new study investigates the effect of the prebiotic BeneoSynergy1 (oligofructose-enriched inulin) in infants with a family history of atopic disease. High risk infants included in the study receive infant formulae either supplemented with BeneoTMSynergy1 (0,8 g/100 ml) or without any supplementation (control group) from birth and throughout the first year of life.
These infants will also be followed during their second year and the overall health and well-being of the infants will be assessed and the composition of their intestinal microbial flora compared. A battery of immunological markers from different body samples (urine, blood and faeces) will also be measured at given time points throughout the study. Clinical outcomes of allergy will be carefully monitored throughout and further follow-up. Thus the study will provide new data on the immuno-modulating effects of BeneoSynergy1 and its potential effect on reducing the risk for allergy during infancy.
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Posted by john on June 23rd, 2007 — in Flonase Top News
ABOUT 30,000 Australians now carry an EpiPen, an adrenalin shot for use in the event of a severe food allergy attack, according to new figures that some doctors believe point to an epidemic of unwarranted anxiety.
Statistics from the Pharmaceutical Benefits Scheme show 35,657 of the devices were ordered last year, up from 21,482 in 2004. More than 4600 scripts were issued this March alone, the highest monthly number yet, amid rising concern about the potential for anaphylaxis - a sudden and potentially fatal allergic reaction that is most commonly associated with peanuts.
Andrew Kemp, professor of pediatric allergy and clinical immunology at the Children’s Hospital at Westmead, said food allergies themselves were on the rise, but EpiPen use appeared to be growing faster.
Publicity about fatal cases of anaphylactic shock, such as that of the Sydney schoolboy Hamidur Rahman, who died after being dared to eat peanut butter at a school camp, had raised awareness, Professor Kemp said.
But despite professional guidelines, it was not always clear who should carry an EpiPen, and parents’ anxiety levels needed to be taken into account.
Ray Mullins, a Canberra allergy specialist, said research had shown severe food allergies were comparable to being dependent on insulin for diabetes, in terms of impact on the ability to live a normal life.
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Associate Professor Mullins said allergy was “almost easier to manage if they’ve had a severe reaction”. In these circumstances any doctor would prescribe EpiPen, but for more marginal cases it was less clear whether the device was valuable. “It depends on how nervous the doctor is, how nervous the parents are.”
Skin reaction tests, in which doctors measure the reaction to an allergen placed on a scratch, predicted the likelihood that a person would react to that substance, though not how severely. If more people were being tested for allergies it was likely a greater number of less severe cases would be diagnosed. “The person may become wedded to the diagnosis of being allergic.”
Guidelines from the Australasian Society of Clinical Immunology and Allergy say EpiPen should only be prescribed if a person has had an anaphylactic reaction, or has had a less severe allergic reaction and also has asthma or heart disease. Specific allergies - to nuts or bee stings, either of which are more often fatal - could also be a reason for prescribing EpiPen.
But Rob Loblay, the director of the allergy unit at Royal Prince Alfred Hospital, said having an EpiPen could be “a liberating experience for many families, to be able to take their kids out socially, anywhere”.
Dr Loblay said a minority - perhaps one in 20 - carried an EpiPen for an allergy they had outgrown. But anaphylaxis, in which the face and throat can swell dramatically, was so frightening that it was understandable some people remained fearful and traumatised. “I’m more concerned about under-prescribing than over-prescribing,” he said.
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Posted by john on June 17th, 2007 — in Flonase Top News
New Australian research has found there is an urgent need for more studies to identify why food allergies in young children are steadily increasing.
An article in the latest Medical Journal of Australia details the research of a Canberra clinical immunologist who has seen a 12-fold increase in the number of children coming to him with allergies from foods like peanuts, egg and milk.
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Dr Raymond Mullins says epidemiological studies need to be done to pinpoint the cause of the dramatic increase.
“We have a food allergy tsunami and we’re not really equipped to deal with it at this stage,” he said.
“We know it is going up, we don’t know why. There’s lots of theories but most of them don’t hold water and we don’t have good strategies to prevent it either.”
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Posted by john on June 13th, 2007 — in Flonase Top News
An industry guide to help people with food allergies was launched today by the Parliamentary Secretary to the Minister for Health and Ageing, Senator Brett Mason.
The revised 2007 Food Industry Guide to Allergen Management and Labelling includes processes to help manufacturers minimise the accidental presence of allergens in foods.
“For the allergic consumer, knowing what is in foods is absolutely essential,” Senator Mason said.
“Developed by the Australian Food and Grocery Council’s (AFGC) Allergen Forum, the guide represents a best-practice approach to managing the presence of accidental allergens in foods, and also addresses the perception that ‘may contain’ statements are unreliable.
“Sometimes there are situations where manufacturers simply can’t eliminate the risk of the accidental presence of allergens occurring in a product. Communicating this information to allergic consumers is very important. The guide outlines a new consistent approach to presenting this information so that allergic consumers can be confident about the foods that they should and should not eat,” he said.
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At present a wide variety of precautionary statements are made about foods that may contain allergens, such as ‘Made on a premises which also uses…’ or ‘Packed on a production line that also handles…’. This could be confusing for allergic consumers, perhaps even leading to some people ignoring these statements and taking a risk. The guide recommends replacing all precautionary statements with the single term ‘May be present:..’.
“This statement should only be made after the food manufacturer has followed all possible procedures to reduce the likelihood of the unintentional presence of an allergen and has determined that the amount of allergen that may be present in the food is sufficient to warrant alerting allergic consumers not to buy the product,” Senator Mason said.
AFGC Deputy CEO Dr David Roberts said that the guide was the culmination of four years work by the food industry and showed the level of their commitment and resolve to ensure consumers were able to make informed choices about the foods they bought.
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Posted by john on June 10th, 2007 — in Flonase Top News
A tranche of previously unseen letters written to Lord Byron by his publisher, John Murray II, revealing the extent of their intimate friendship, is about to be published.
The correspondence, which spans an 11-year period from 1811, charts an exchange that began as a business arrangement, but grew much closer, culminating in Murray burying Byron’s illegitimate daughter, Allegra, in London after the poet sent her body back from Italy. The letters reveal how, exiled in Italy Byron relied on Murray to be his lifeline to events back home.
Murray, who began work as a bookseller, was a shrewd businessman who found prosperity when he discovered Byron and published Childe Harold’s Pilgrimage, which sold 500 copies in five days, prompting Byron to comment: “I awoke one morning and found myself famous.”
The relationship later soured after Murray began changing Byron’s poems without informing him, much to Byron’s annoyance. “After Byron died, a note was brought back to Murray, which said, ‘Among all his friends, he found you one of the best.’ It’s a very extraordinary thing that there is Lord Byron at the very end saying: ‘Go back to Murray and tell him you were one of my best friends’,” said John Murray VII, the seventh in the line of publishers.
He added: “The fact that Murray was a tradesman is what makes this correspondence extraordinary. Lord Byron, as a writer, should be writing to his publisher about publishing matters - not about his latest conquests in Venice. Or indeed, sending him things like tooth-powder, gunpowder and bulldogs. This is not the normal thing for a publisher to do.
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Bernard Beatty, the vice-president of the Byron Society, said: “So much [is] written about Byron that only shows his flamboyant side. He was also very much a straightforward, ordinary human being.”
Extract: ‘For heaven’s sake revise it’
In this 1822 letter to Byron, Murray explains to the enraged poet why he decided to cut several sections of the epic poem ‘Don Juan’.
Dear Lord Byron
Mr Kinnaird sent me the 3 Cantos of ‘Don Juan’ and with them, very ungenerously I think, your angry letter. Mr Kinnaird read to me a few days before, the preface & many extracts from the poem - and I declare to you, these were so outrageously shocking that I would not publish them. For heaven’s sake revise them. It is well worth while to extract what would shock the feeling of every man in the country and do your name everlasting injury.
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Posted by john on June 5th, 2007 — in Flonase Top News
The first new nasal spray on the market in years has just been approved by the Food and Drug Administration. Veramyst (fluticasone furoate), from the makers of Flonase, is approved to treat seasonal and year-round allergies in adults and children older than 2 years of age. In addition, Veramyst has been shown to treat eye allergies in children 12 years and older.
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Unlike Flonase, which many people don’t like due to the flowery smell, Veramyst is scent-free. And, Veramyst has a mist-release button on the side of the container, making it easier to keep the nozzle inside the nose while using the medication. All other prescription nasal sprays currently use a pump device on the top of the container, making it more difficult to keep the nozzle in place during medication delivery.
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